There are a few papers that have caught our attention recently, and I thought I would share them with you. This won't be news for many of you who read the journals as they come out.

1. "Virtual exploration of the Chemical Universe...", the second paper, by Fink and Reymond. http://dx.doi.org/10.1021/ci600423u

This work by Reymond enables us to begin to ask quantitative questions about chemical space, at least at low molecular weight. I think this database can be a very useful, pragmatic way to think about "what are we missing in chemical space?"

2. Brian Kobilka's breakthrough work on the beta-2 adrenergic receptor, the first GPCR drug target solved to atomic resolution.
http://www.sciencemag.org/cgi/content/abstract/318/5854/1266

3. "Therapeutic targets" paper out of Singapore by Zheng CJ, Han LY, Yap CW, Ji ZL, Cao ZW, Chen YZ. A very handy review of pharmaceutical targets. Lots of data to pour over. Nicely presented.
http://pharmrev.aspetjournals.org/cgi/pmidlookup?view=long&pmid=16714488